Anti-anxiety, Anti-depressant and Anti- Cataleptic Activity of 4-hydroxy-3-[2-(3-nitrophenyl)-2, 3-dihydro-1, 5- Benzothiazepin-4-yl]-2h-chromen-2-one
نویسندگان
چکیده
The Present study was aimed to evaluate the therapeutic effectiveness of 1, 5-benzothiazapine derivative in central nervous diseases. 1,5Benzothiazipines are the seven–membered heterocyclic ring systems which are reported for their behavioral activities. In the current research, we have investigated the effect of 1,5-benzothiazine derivative for its anti-anxiety, antidepressant and anti-cataleptic activities by using elevated plus maze, forced swim test and chlorpromazine induced catalepsy respectively. Wistar rats were treated with 1, 5benzothiazapine derivative (5mg/kg, p.o. daily) for 30 days. The results showed significant (p<0.01) anti-anxiety, anti-depressant and anti-cataleptic actions of 1, 5-benzothiazapine derivative. Here we suggested that, these drugs can be further studied in Preclinical and Clinical level for the treatment of central nervous diseases.
منابع مشابه
Synthesis, Invivo Analgesic and Invitro Anti-microbial Activity Of3-amino-4-[2- (substituted Phenyl) Hydrazin-1-ylidene]-1-[(2- Oxo-2h-chromen-3-yl) Carbonyl]-4, 5-dihydro-1h- Pyrazol-5-one and Its Schiff Bases
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